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Gene could rejuvenate old hearts

Computer files stored accurately on DNA in new breakthrough

The hearts of newborns have the remarkable capacity to heal themselves after injury by generating new heart cells but we lose this ability shortly after birth.
Now researchers have for the first time identified the gene which causes this change, allowing cells to continue dividing and potentially giving the adult heart the same regenerative power.
In experiments on rats, deleting the Meis1 gene allowed the heart cells of newborn mice to keep dividing for longer, and reactivated the regeneration process in adults without impeding the normal working of the heart.
Results also showed that making the gene more active in newborn mice prevented their cells from dividing and regenerating damaged tissue.
The findings suggest that deactivating the gene could lead to new treatments for adult heart failure patients and offer an alternative to stem cell therapies currently being developed, researchers said.
The hearts of newborns have the remarkable capacity to heal themselves after injury by generating new heart cells but we lose this ability shortly after birth.
Now researchers have for the first time identified the gene which causes this change, allowing cells to continue dividing and potentially giving the adult heart the same regenerative power.
In experiments on rats, deleting the Meis1 gene allowed the heart cells of newborn mice to keep dividing for longer, and reactivated the regeneration process in adults without impeding the normal working of the heart.
Results also showed that making the gene more active in newborn mice prevented their cells from dividing and regenerating damaged tissue.
The findings suggest that deactivating the gene could lead to new treatments for adult heart failure patients and offer an alternative to stem cell therapies currently being developed, researchers said.

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