Skip to main content

Scientists have finally figured out how cancer spreads through the bloodstream

In what could be a major step forward in our understanding of how cancer moves around the body, researchers have observed the spread of cancer cells from the initial tumour to the bloodstream.
The findings suggest that secondary growths called metastases 'punch' their way through the walls of small blood vessels by targeting a molecule known as Death Receptor 6 (no, really, that's what it's called). This then sets off a self-destruct process in the blood vessels, allowing the cancer to spread.
According to the team from Goethe University Frankfurt and the Max Planck Institute in Germany, disabling Death Receptor 6 (DR6) may effectively block the spread of cancerous cells - so long as there aren't alternative ways for the cancer to access the bloodstream.
"This mechanism could be a promising starting point for treatments to prevent the formation of metastases," said lead researcher Stefan Offermanns.
Catching these secondary growths is incredibly important, because most cancer deaths are caused not by the original tumour, but by the cancer spreading.
To break through the walls of blood vessels, cancer cells target the body's endothelial cells, which line the interior surface of blood and lymphatic vessels. They do this via a process known as necroptosis - or 'programmed cell death' - which is prompted by cellular damage.
According to the researchers, this programmed death is triggered by the DR6 receptor molecule. Once the molecule is targeted, cancer cells can either travel through the gap in the vascular wall, or take advantage of weakening cells in the surrounding area.
The team observed the same behaviour in both lab-grown cells and mice. In genetically modified mice where DR6 was disabled, less necroptosis and less metastasis was recorded.
The scientists have reported their findings in Nature.
The next step is to look for potential side effects caused by the disabling of DR6, and to figure out if the same benefits can be seen in humans. If so – and there's no guarantee of that – this has the potential to be a seriously effective way of slowing down the spread of cancer. 
There are other hypotheses on how some metastases get around the body to cause secondary growths, though. Scientists at the University of California, Los Angeles (UCLA) are currently investigating the idea that tumour cells could also spread through the body outside blood vessels and the bloodstream.
The researchers suggest that a mechanism known as angiotropism could be used by some melanoma cancers to cling to the outside of blood vessels, rather than penetrating them. If this is confirmed, they would escape the effects of disabled DR6 and chemotherapy alike.
"If tumour cells can spread by continuous migration along the surfaces of blood vessels and other anatomical structures such as nerves, they now have an escape route outside the bloodstream," explained researcher Laurent Bentolilafrom UCLA. 
The findings from that research, also conducted on mice, have been published in Nature Scientific Reports.
As the two studies show, not all cancers behave in the same way, which makes figuring out how they operate doubly difficult. But the more we come to appreciate how complex and varied this disease can be, the better chance we have of fighting it.

Comments

Post a Comment

Popular posts from this blog

Einstein’s Lost Theory Describes a Universe Without a Big Bang

Einstein with Edwin Hubble, in 1931, at the Mount Wilson Observatory in California, looking through the lens of the 100-inch telescope through which Hubble discovered the expansion of the universe in 1929.  Courtesy of the Archives, Calif Inst of Technology. In 1917, a year after Albert Einstein’s  general theory of relativity  was published—but still two years before he would become the international celebrity we know—Einstein chose to tackle the  entire universe . For anyone else, this might seem an exceedingly ambitious task—but this was Einstein. Einstein began by applying his  field equations of gravitation  to what he considered to be the entire universe. The field equations were the mathematical essence of his general theory of relativity, which extended Newton’s theory of gravity  to realms where speeds approach that of light and masses are very large. But his math was better than he wanted to believe—...
Post a Comment
Read more

There’s a Previously Undiscovered Organ in Your Body, And It Could Explain How Cancer Spreads

Ever heard of the interstitium? No? That’s OK, you’re not alone  —  scientists hadn’t either. Until recently. And, hey, guess what  —  you’ve got one! The interstitium is your newest organ. Scientists identified it for the first time because they are better able to observe living tissues at a microscopic scale, according to a recent study published  in  Scientific Reports , Scientists had long believed that connective tissue surrounding our organs was a thick, compact layer. That’s what they saw when they looked at it in the lab, outside the body, at least. But in a routine endoscopy (exploration of the gastrointestinal tract), a micro camera revealed something unexpected: When observed in a living body, the connective tissue turned out to be “an open, fluid-filled space supported by a lattice made of thick collagen bundles,” pathologist and study author Neil Theise  told  Research Gate . This network of channels is present throughout ...
Post a Comment
Read more

First light-bending calculator designed with metamaterials

Exotic materials that bend light in extreme ways could be used to perform complex mathematical operations, creating a new kind of analogue computer. Tools for manipulating light waves have taken off in recent years thanks to the development of  metamaterials . These materials have complex internal structures on scales smaller than the wavelength of the light they interact with, and so they produce unusual effects. Most famously, metamaterials promise to deliver " invisibility cloaks " that can route light around an object, making it seem to disappear. Nader Engheta  at the University of Pennsylvania, Philadelphia, and his colleagues decided to explore a different use for metamaterials, one that adapts the  old idea of analogue computing . Today's digital computers are based on electrical switches that are either on or off. But before these machines were analogue computers based on varying electrical or mechanical properties. The  slide rule  is one example...
Post a Comment
Read more